Timing of excision after a non-severe burn has a significant impact on the subsequent immune response in a murine model.
MouseBurnUnspecifiedC57BL/6FemaleSurgical excision of the burn woundEarly excision on day 1 after burn versus late excision on day 8 after burn
Model: Full-thickness burn covering less than 8% total body surface area, followed by surgical excision
Early excision preserved innate and adaptive immune cell responses, whereas late excision provoked an acute severe inflammatory response with elevated inflammatory cytokines, Th2-promoting cytokines, and increased neutrophil, eosinophil and monocyte infiltration, followed by loss of inflammatory de…
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