THERAPY DOSSIER · th-bfc58ea6600f

Surgical burn wound excision (early versus late timing)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01749371 ↗Injury indicationPHASE2/PHASE3completed

INDICATION-LEVEL SURROGATE: Vitamin E Supplementation in Burned Patients

Burn

Enrolment: 27 · Results not recorded

NCT04965883 ↗Injury indicationNAunknown

Comparison Between Early Excision and Grafting Versus Dressing and Delayed Grafting in Deep Burn Management

Burns

Enrolment: 40 · Results not recorded

NCT02940171 ↗Injury indicationPhase not recordedterminated

Impact of Timing of Surgery on Outcome of Severely Ill Burn Patients (early versus late full-thickness burn excision)

Burns

Enrolment: 470 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26880298 ↗2016Reported benefit

Timing of excision after a non-severe burn has a significant impact on the subsequent immune response in a murine model.

MouseBurnUnspecifiedC57BL/6FemaleSurgical excision of the burn woundEarly excision on day 1 after burn versus late excision on day 8 after burn

Model: Full-thickness burn covering less than 8% total body surface area, followed by surgical excision

Early excision preserved innate and adaptive immune cell responses, whereas late excision provoked an acute severe inflammatory response with elevated inflammatory cytokines, Th2-promoting cytokines, and increased neutrophil, eosinophil and monocyte infiltration, followed by loss of inflammatory de…

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

Loading the evidence…