The Effect of the iNOS Inhibitor S-Methylisothiourea and Hyperbaric Oxygen Treatment on Radiation Colitis in Rats.
RatRadiationSprague-DawleyFemalen = 60 rats in five equal groups of 12SMT intraperitoneal; HOT inhaled hyperbaric oxygenSMT 10 mg/kg/day; HOT 100 per cent oxygen at 2.5 atmStarted after irradiation, exact interval not stated
Model: Acute radiation colitis induced by a single 25 Gy dose of gamma irradiation delivered to the colorectal region of anaesthetised rats
SMT, HOT and their combination reduced TNF-alpha, IL-1beta, IL-10 and TGF-beta and improved colitis histology and weight loss versus control, with the combination most effective; ICAM-1 mRNA was not significantly changed.
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