THERAPY DOSSIER · th-655985a6e0fb

S-Methylisothiourea (SMT), with hyperbaric oxygen treatment alone and in combination

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: SMT
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26852757 ↗2016Reported benefit

The Effect of the iNOS Inhibitor S-Methylisothiourea and Hyperbaric Oxygen Treatment on Radiation Colitis in Rats.

RatRadiationSprague-DawleyFemalen = 60 rats in five equal groups of 12SMT intraperitoneal; HOT inhaled hyperbaric oxygenSMT 10 mg/kg/day; HOT 100 per cent oxygen at 2.5 atmStarted after irradiation, exact interval not stated

Model: Acute radiation colitis induced by a single 25 Gy dose of gamma irradiation delivered to the colorectal region of anaesthetised rats

SMT, HOT and their combination reduced TNF-alpha, IL-1beta, IL-10 and TGF-beta and improved colitis histology and weight loss versus control, with the combination most effective; ICAM-1 mRNA was not significantly changed.

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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