Transplantation of neural progenitor cells in chronic spinal cord injury.
RatSpinal cord injuryContusionFischer 344 transgenic donor embryos (alkaline phosphatase reporter); adult female recipient rats from TaconicFemalen = 45 rats used, 39 contused: Medium n=9, NPC n=10, NPC plus C…Intraspinal injection into and around the lesion10 ul of cell suspension at 1 x 10^5 cells/ul (4 ul at lesi…Cells transplanted 13 weeks after contusion; lentiviral vectors injected one we…
Model: Moderate T10 contusion spinal cord injury using the NYU impactor (10 g weight dropped 25 mm), allowed to become chronic for 13 weeks before treatment
Graft survival was variable (NPCs present at the injury site in about 60 per cent of animals, occupying less than 40 per cent of the lesion) and there was no improvement in locomotor, grid or allodynia outcomes, but the combination group receiving NPCs with chondroitinase and neurotrophins showed b…
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