THERAPY DOSSIER · th-2c8b20a1be8a

Embryonic spinal cord neural progenitor cells (NPCs), alone or combined with lentiviral chondroitinase (Chase/LV) and lentiviral BDNF and NT-3

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 9

9 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02163876 ↗Injury indicationPHASE2terminated

MODALITY-LEVEL SURROGATE: Phase II Human CNS Stem Cells (HuCNS-SC) Transplantation in Cervical Spinal Cord Injury

Cervical Spinal Cord Injury

Enrolment: 31 · Results not recorded

NCT02688049 ↗Injury indicationPHASE1/PHASE2unknown

MODALITY-LEVEL SURROGATE: NeuroRegen Scaffold With Mesenchymal or Neural Stem Cells for Chronic Spinal Cord Injury Repair

Spinal Cord Injury

Enrolment: 30 · Results not recorded

NCT02302157 ↗Injury indicationPHASE1/PHASE2completed

MODALITY-LEVEL SURROGATE: Phase 1/2a Dose Escalation of AST-OPC1 in Subacute Cervical Spinal Cord Injury

Cervical Spinal Cord Injury

Enrolment: 25 · Results not recorded

NCT01321333 ↗Injury indicationPHASE1/PHASE2completed

MODALITY-LEVEL SURROGATE: Phase I/II Intramedullary Transplantation of HuCNS-SC in Thoracic Spinal Cord Trauma

Thoracic Spinal Cord Injury

Enrolment: 12 · Results not recorded

NCT02326662 ↗Injury indicationPHASE1/PHASE2unknown

MODALITY-LEVEL SURROGATE: Autologous Neural Stem Cell Transplantation in Traumatic Spinal Cord Injury

Spinal Cord Injury

Enrolment: 30 · Results not recorded

NCT04812431 ↗Injury indicationPHASE1/PHASE2recruiting

MODALITY-LEVEL SURROGATE: Phase 1/2a PSA-NCAM(+) Neural Precursor Cells From hESC in AIS-A Sub-acute SCI

Spinal Cord Injury, Acute

Enrolment: 5 · Results not recorded

NCT01772810 ↗Injury indicationPHASE1unknown

MODALITY-LEVEL SURROGATE: Phase 1 Human Spinal Cord-derived Neural Stem Cell Transplantation for Chronic SCI

Spinal Cord Injury

Enrolment: 8 · Results not recorded

NCT07253233 ↗Injury indicationEARLY_PHASE1not yet recruiting

INDICATION-LEVEL SURROGATE: Spinal Cord Injury Treated With Autologous Concentrated Growth Factors

Spinal Cord Injury

Enrolment: 10 · Results not recorded

NCT01725880 ↗Injury indicationPhase not recordedterminated

MODALITY-LEVEL SURROGATE: Long-term Follow-up of Intramedullary HuCNS-SC in Thoracic Spinal Cord Trauma

Spinal Cord Injury

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26852702 ↗2016Mixed findings

Transplantation of neural progenitor cells in chronic spinal cord injury.

RatSpinal cord injuryContusionFischer 344 transgenic donor embryos (alkaline phosphatase reporter); adult female recipient rats from TaconicFemalen = 45 rats used, 39 contused: Medium n=9, NPC n=10, NPC plus C…Intraspinal injection into and around the lesion10 ul of cell suspension at 1 x 10^5 cells/ul (4 ul at lesi…Cells transplanted 13 weeks after contusion; lentiviral vectors injected one we…

Model: Moderate T10 contusion spinal cord injury using the NYU impactor (10 g weight dropped 25 mm), allowed to become chronic for 13 weeks before treatment

Graft survival was variable (NPCs present at the injury site in about 60 per cent of animals, occupying less than 40 per cent of the lesion) and there was no improvement in locomotor, grid or allodynia outcomes, but the combination group receiving NPCs with chondroitinase and neurotrophins showed b…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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