Neuroprotective Effects of Hydrogen Sulfide Against Early Brain Injury and Secondary Cognitive Deficits Following Subarachnoid Hemorrhage.
RatHaemorrhage/shockUnspecifiedWistarMaleIntraperitoneal injection5.6 mg/kgFirst dose 2 h after subarachnoid haemorrhage
Model: Experimental subarachnoid haemorrhage with early brain injury and secondary cognitive deficits
NaHS reduced brain oedema and neuronal death, improved neurobehavioural function at 48 h and improved Morris water maze learning and memory at 7 days, with a lower Bax/Bcl-2 ratio, suppressed caspase-3 activation and increased phospho-Akt, phospho-ERK, BDNF and phospho-CREB.
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