IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation.
MouseOtherC57BL/6 wild-type and IL-10 knockoutn = n = 6 to 8 per group in the in vivo experimentsIntraperitoneal injection50 ug/kgFollowing carotid artery injury; exact interval to the first dose not stated
Model: Carotid artery denudation by wire injury under anaesthesia
Systemic IL-10 significantly accelerated re-endothelialisation at days 5 and 7 and reduced intimal and medial areas at day 28 versus IgG control, while IL-10 knockout mice showed delayed re-endothelialisation and enhanced neointimal growth.
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