THERAPY DOSSIER · th-077ee464dc34

Recombinant murine interleukin-10 (IL-10)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL4297771 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: Human interleukin-10; IL-10; Interleukin-10
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00001797 ↗PHASE2completed

Recombinant Human Interleukin-10 for Moderate-to-Severe Psoriasis

Psoriasis

Enrolment: 36 · Results not recorded

NCT00040131 ↗PHASE2terminated

IL-10 (Tenovil) in Prevention of Post-ERCP Acute Pancreatitis

Bile Duct Diseases · Pancreatitis · Pancreatic Diseases

Enrolment: 316 · Results not recorded

NCT03477487 ↗PHASE1completed

Safety/Efficacy of XT-150 (IL-10 variant plasmid DNA) for Osteoarthritic Pain

Osteoarthritis, Knee

Enrolment: 32 · Results not recorded

NCT00001761 ↗PHASE1completed

Phase I Trial of Recombinant Human Interleukin-10 (SCH 52000) in Wegener's Granulomatosis

Vasculitis · Wegener's Granulomatosis

Enrolment: 15 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26808574 ↗2016Reported benefit

IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation.

MouseOtherC57BL/6 wild-type and IL-10 knockoutn = n = 6 to 8 per group in the in vivo experimentsIntraperitoneal injection50 ug/kgFollowing carotid artery injury; exact interval to the first dose not stated

Model: Carotid artery denudation by wire injury under anaesthesia

Systemic IL-10 significantly accelerated re-endothelialisation at days 5 and 7 and reduced intimal and medial areas at day 28 versus IgG control, while IL-10 knockout mice showed delayed re-endothelialisation and enhanced neointimal growth.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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