Acute versus chronic phase mechanisms in a rat model of CRPS.
RatFractureTibiaSprague Dawleymalen = Rats randomly assigned to four primary cohorts (4-week cont…intraperitoneal, subcutaneous injection or osmotic pump, and intrathecalNK1 receptor antagonist 30 mg/kg/day intraperitoneally or 1…Treatments given in the period preceding behavioural testing at 4 weeks and at…
Model: Distal tibia fracture under isoflurane anaesthesia followed by hindlimb cast immobilisation for 4 weeks, a model of complex regional pain syndrome
At 4 weeks after fracture, systemic NK1 antagonist, anakinra and anti-NGF each reduced or abolished hindpaw allodynia and unweighting and reduced the interpaw temperature difference, with effect sizes of 30 to 50 per cent for warmth and no significant effect on edema. By 16 weeks the systemic treat…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.