Tranilast ameliorates cyclophosphamide-induced lung injury and nephrotoxicity.
MouseChemical/toxinSwiss Albinomaleoral
Model: Intraperitoneal cyclophosphamide causing acute and subacute lung injury and nephrotoxicity
Tranilast increased lung and kidney superoxide dismutase activity and glutathione, reduced lipid peroxidation, lowered serum creatinine, blood urea nitrogen, TNF-alpha and lactate dehydrogenase, reduced pulmonary inflammatory cell accumulation and improved tissue histology.
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