Effect of Inflammasome Inhibitor (incl. Tranilast) on hsCRP After Percutaneous Coronary Intervention
NLRP3 · hsCRP · PCI
Enrolment: 132 · Results not recorded
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Drug · No mechanism_of_action record in ChEMBL for CHEMBL415324 (USAN stem '-ast', antiasthmatic/antiallergic). Mast cell stabilisation, TGF-beta and NLRP3 inflammasome inhibition are literature-reported, not asserted by the ChEMBL MoA table.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
NLRP3 · hsCRP · PCI
Enrolment: 132 · Results not recorded
Pterygium
Enrolment: 32 · Results not recorded
Rheumatoid Arthritis
Enrolment: 250 · Results not recorded
Esophageal Stricture · Esophageal Neoplasms
Enrolment: 394 · Results not recorded
Nasopharyngeal Carcinoma
Enrolment: 18 · Results not recorded
Cryopyrin-Associated Periodic Syndromes
Enrolment: 71 · Results not recorded
Scleredema Adultorum
Enrolment: 56 · Results not recorded
Mucinoses
Enrolment: 56 · Results not recorded
Rheumatoid Arthritis
Enrolment: 0 · Results not recorded
Benign Prostatic Hyperplasia
Enrolment: 30 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Intraperitoneal cyclophosphamide causing acute and subacute lung injury and nephrotoxicity
Tranilast increased lung and kidney superoxide dismutase activity and glutathione, reduced lipid peroxidation, lowered serum creatinine, blood urea nitrogen, TNF-alpha and lactate dehydrogenase, reduced pulmonary inflammatory cell accumulation and improved tissue histology.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Thioacetamide-induced acute liver injury with hepatic encephalopathy
Tranilast improved hepatic function, restored oxidant/antioxidant balance, lowered serum nitric oxide, IL-6 and IL-13, reduced serum ammonia and decreased astrocyte swelling and vacuolisation.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Spinal cord injury by impaction
Both intravenous and oral tranilast improved motor recovery, reduced acute inflammatory cell invasion and Iba1 expression, and confined glial and fibrotic scarring with lower chondroitin sulfate levels than control.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Subcutaneous silicone implant placement provoking foreign body reaction and fibrous capsule formation over 12 weeks
Early local tranilast release significantly reduced capsule thickness and collagen density at 12 weeks, with fewer differentiated macrophages and less TGF-beta and fibroblast accumulation.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Carbon tetrachloride induced acute liver injury in rats
Nanocrystalline tranilast at 2 mg/kg every 12 h markedly attenuated hepatic damage with lower alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and reactive oxygen species, whereas the physical mixture was less effective.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.