Delayed application of the haematopoietic growth factors G-CSF/SCF and FL reduces neonatal excitotoxic brain injury.
MouseOtherintraperitonealstarting 60 h after the excitotoxic insult
Model: Established neonatal mouse model of excitotoxic brain injury mediated by N-methyl-D-aspartate receptor activation
Delayed intraperitoneal G-CSF/SCF and FL significantly reduced lesion size at postnatal days 10, 18 and 90. G-CSF/SCF reduced caspase-3 activation, while neither treatment affected apoptosis-inducing factor dependent apoptosis or cell proliferation.
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