Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- G-CSF; SCF; FL; filgrastim; ancestim
- Note
- Not recorded
Clinical trials 5
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
G-CSF Stimulated Bone Marrow vs Conventional Bone Marrow as Stem Cell Source in Matched Sibling Donor Transplantation
Childhood Acute Lymphoblastic Leukemia in Remission · Childhood Acute Myeloid Leukemia in Remission · Myelodysplastic Syndromes
Enrolment: 27 · Results not recorded
Hematopoietic Stem Cell Therapy for Patients With Refractory Myasthenia Gravis
Myasthenia Gravis
Enrolment: 9 · Results not recorded
A Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haploidentical Peripheral Blood Stem Cell Transplantation
Acute Leukemia in Remission · Myelodysplastic Syndromes · Multiple Myeloma
Enrolment: 32 · Results not recorded
T Cell Depletion in the Setting of Autologous Stem Cell Transplantation for Patients With Multiple Myeloma
Myeloma
Enrolment: 30 · Results not recorded
Feasibility and Safety of GCSF Mobilization of CD34+ Hematopoietic Progenitor Cells in Beta-thalassemia Major
Beta Thalassemia Major · Congenital Anemias
Enrolment: 5 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseOtherintraperitonealstarting 60 h after the excitotoxic insult
Model: Established neonatal mouse model of excitotoxic brain injury mediated by N-methyl-D-aspartate receptor activation
Delayed intraperitoneal G-CSF/SCF and FL significantly reduced lesion size at postnatal days 10, 18 and 90. G-CSF/SCF reduced caspase-3 activation, while neither treatment affected apoptosis-inducing factor dependent apoptosis or cell proliferation.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.