Epidermal growth factor attenuates blood-spinal cord barrier disruption via PI3K/Akt/Rac1 pathway after acute spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 5 per group for blots and BBB scoring, 4 per group for Evan…Subcutaneous near the wound for EGF; intrathecal for LY294002EGF 60 microg/kg; PI3K inhibitor LY294002 50 nmol/kg in 5 m…Started immediately after injury
Model: T9 laminectomy with moderate contusion spinal cord injury, 150 kdyn with no dwell time using an Infinite Horizon impactor
EGF preserved blood-spinal cord barrier integrity and improved locomotor recovery through PI3K/Akt/Rac1 dependent maintenance of junction proteins.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.