Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase.

Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase.

Model: Traumatic brain injury with assessment of mesenteric artery function 24 h later

Traumatic brain injury impaired endothelium dependent dilation of mesenteric arteries through arginase driven eNOS uncoupling, and exogenous L-arginine or arginase inhibition restored endothelial function.

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