Drug
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Fracture Healing · Atrophic Non Union Development · Hypertrophic Non Union Development
Enrolment: 100 · Results not recorded
Alcoholic Hepatitis
Enrolment: 0 · Results not recorded
Classic Galactosemia
Enrolment: 4 · Results not recorded
Peripheral Vascular Disease · Claudication
Enrolment: 6 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Moderate spinal cord injury
Early L-arginine worsened long-term locomotor recovery after spinal cord injury, suggesting neurotoxicity.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Aristolochic acid nephropathy induced by daily intraperitoneal injection of aristolochic acid I at 3.5 mg/kg body weight for 4 days
L-arginine restored renal nitric oxide bioavailability and reduced tubular injury, inflammatory infiltration and interstitial fibrosis, lessening the severity of the acute-to-chronic transition, with the clearest functional benefit at day 10 and only partial prevention of polyuria at day 20.
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.
Model: Traumatic brain injury with assessment of mesenteric artery function 24 h later
Traumatic brain injury impaired endothelium dependent dilation of mesenteric arteries through arginase driven eNOS uncoupling, and exogenous L-arginine or arginase inhibition restored endothelial function.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Aristolochic acid nephropathy induced by daily intraperitoneal aristolochic acid 2.5 mg/kg for 4 days
L-arginine supplementation significantly increased nitric oxide bioavailability and improved both renal function and renal structure after aristolochic acid intoxication, with reduced Nox2 expression, lower reactive oxygen species production and increased antioxidant concentrations.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Rectangular 1.5 cm x 1 cm dorsal skin wound excised to the level of the panniculus carnosus, in streptozotocin-induced diabetic and normoglycaemic rats
Systemic L-arginine produced significantly higher wound fluid nitrite than topical L-arginine and a significantly better histological healing score in diabetic rats; VEGF corrected for total protein was raised in all L-arginine treated groups relative to controls.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
