PRECLINICAL PUBLICATION · 2016

Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice.

Mouse / Haemorrhage/shock

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

AE1-259-01, selective EP2 receptor agonist

PMID 26746866 ↗2016Reported benefit

Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice.

MouseHaemorrhage/shockUnspecifiedMale

Model: Intracerebral haemorrhage induced by intrastriatal collagenase injection or intrastriatal autologous arterial whole blood injection

EP2 receptor activation with AE1-259-01 reduced brain injury, oedema and neurological deficits after intracerebral haemorrhage, whereas EP2 deletion worsened outcomes.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.