Evidence & regulatory context
- Mechanism
- AE1-259-01 is a selective prostaglandin EP2 receptor agonist (research tool); no confident ChEMBL name match returned
- Target
- Not recorded
- Injury models
- Haemorrhage/shock
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseHaemorrhage/shockUnspecifiedMale
Model: Intracerebral haemorrhage induced by intrastriatal collagenase injection or intrastriatal autologous arterial whole blood injection
EP2 receptor activation with AE1-259-01 reduced brain injury, oedema and neurological deficits after intracerebral haemorrhage, whereas EP2 deletion worsened outcomes.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
