Resolvin D1 protects against inflammation in experimental acute pancreatitis and associated lung injury.
MouseChemical/toxinC57BL/6Not stated in the abstract300 ng per mouse30 min before the first cerulein injection
Model: Cerulein induced acute pancreatitis, or cerulein combined with lipopolysaccharide for severe acute pancreatitis with associated lung injury
Resolvin D1 pretreatment lowered serum amylase, lipase and cytokines, reduced pancreatic and pulmonary myeloperoxidase activity and NF-kappaB activation and lessened histological injury, most notably in severe pancreatitis.
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