Preclinical evidence 4
4 studies reported at therapy level; 4 evidence entries itemised.
RatOtherWistarMaleIn vivo administration; ALX/FPR2 neutralisation given intracerebroventricularlyAfter hemicerebellectomy
Model: Hemicerebellectomy, a model of focal brain injury with remote secondary damage
Resolvin D1 promoted functional recovery and neuroprotection by reducing microglial and astrocytic activation and inflammation-driven neuronal death in remote regions, effects reversed by ALX/FPR2 neutralisation.
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.
MouseChemical/toxinC57BL/6Not stated in the abstract300 ng per mouse30 min before the first cerulein injection
Model: Cerulein induced acute pancreatitis, or cerulein combined with lipopolysaccharide for severe acute pancreatitis with associated lung injury
Resolvin D1 pretreatment lowered serum amylase, lipase and cytokines, reduced pancreatic and pulmonary myeloperoxidase activity and NF-kappaB activation and lessened histological injury, most notably in severe pancreatitis.
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MouseChemical/toxinC57BL/6JFemalen = n = 6 to 7 mice per group for lavage differential counts; n…Oropharyngeal aspiration (inhalation)100 ng RvD1 or 100 ng 17R-RvD1 in 40 microlitres salinePre-treatment model: on day 0 and 1 hour before the first smoke exposure on day…
Model: Acute cigarette smoke-induced lung inflammation, dilute mainstream smoke for 1 hour twice daily for 3 days at nominal 450 mg/m3 total suspended particulate; the resolution model used 2 hours per day on days 1 to 3
RvD1 given concurrently with cigarette smoke significantly reduced lavage neutrophils, total protein, KC, MIP-2, interleukin-1beta, interleukin-6, prostaglandin E2 and COX-2, and increased interleukin-10, while promoting M2 macrophage polarisation and neutrophil efferocytosis. A single dose of 17R-…
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MouseWoundB6.BKS(D)-Lepr(db)/J (db/db) and wild-type C57BL/6JMalen = Wound closure n=5 to 9; granulation tissue area and Fpr2 n=…Topical application to the wound bed plus four intradermal injections of 10 microlitres per site; retro-orbital injection in the thymocyte modelWounds, 100 ng in 50 microlitres per wound per day; thymocy…Wounds, first dose 24 h after wounding; peritonitis, 32 h after zymosan with ex…
Model: Two 5 mm full-thickness excisional dorsal skin wounds with silicone splinting to prevent contraction; secondary models of zymosan A-induced peritonitis at 0.04 mg/g intraperitoneally and dexamethasone-induced thymocyte apoptosis at 15 mg/kg intraperitoneally
Local resolvin D1 accelerated closure of splinted cutaneous wounds in diabetic db/db mice, with smaller wound diameter by day 8, more granulation tissue and fewer apoptotic cells and CD68-positive macrophages than vehicle.
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.
