Local versus distal transplantation of human neural stem cells following chronic spinal cord injury.
RatSpinal cord injuryContusionLong-Evans hoodedFemalen = 24 rats, 6 per group across four groupsSubdural injection at the injury site, or intrathecal injection through a separate distal laminotomy4 weeks after contusion injury
Model: T10 laminectomy with moderate contusion using the MASCIS impactor, 10 g weight dropped from 25 mm, treated in the chronic phase 4 weeks after injury
Distal intrathecal delivery of human neural stem cells significantly improved locomotor score compared with control (p = 0.042), whereas local subdural delivery did not reach significance (p = 0.085).
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