A Randomized Phase II Study of Subventricular Zone (SVZ) Irradiation Plus Temozolomide in Newly Diagnosed Glioblastoma Multiforme
Glioblastoma Multiforme
Enrolment: 60 · Results not recorded
Loading the evidence…
Biologic
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Glioblastoma Multiforme
Enrolment: 60 · Results not recorded
Ischaemic Stroke · Cerebral Infarction · Hemiparesis · Arm Paralysis
Enrolment: 23 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 30 · Results not recorded
Parkinson's Disease
Enrolment: 0 · Results not recorded
Multiple System Atrophy Parkinsonian Variant (MSA-P)
Enrolment: 3 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 18 · Results not recorded
Neuromyelitis Optica Spectrum Disorders
Enrolment: 69 · Results not recorded
Parkinson's Disease · Parkinsonism
Enrolment: 0 · Results not recorded
Obesity, Morbid
Enrolment: 6 · Results not recorded
Hematopoietic Stem Cell Transplant · Hematologic Diseases
Enrolment: 84 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: T9 spinal cord transection
NSC transplanted rostral to the transection at the subacute stage gave the best graft survival and locomotor improvement with least macrophage infiltration.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: T10 laminectomy with moderate contusion using the MASCIS impactor, 10 g weight dropped from 25 mm, treated in the chronic phase 4 weeks after injury
Distal intrathecal delivery of human neural stem cells significantly improved locomotor score compared with control (p = 0.042), whereas local subdural delivery did not reach significance (p = 0.085).
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Spinal cord transection
Neural stem cell grafts significantly improved sensory and locomotor function and increased BDNF protein and mRNA at the injury site, with somatosensory evoked potentials recorded in grafted rats despite little corticospinal tract regeneration.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Spinal cord transection
Neural stem cell transplantation significantly improved hindlimb locomotor function. Only BDNF and NT-3 mRNA, not NGF, were markedly upregulated in the injured segment, with simultaneous downregulation of caspase-3. Little corticospinal tract regeneration was seen.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.