Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury.
RatTBIPenetrating / ballisticSprague-DawleyMaleExtraluminal cooling of the bilateral common carotid arteriesTarget brain temperature 34 degrees CInitiated immediately, or with a 2 h or 4 h delay after injury
Model: Penetrating ballistic-like brain injury
Selective brain cooling reduced lesion volume, axonal pathology, neuroinflammation and post-traumatic seizures and improved rotarod performance including after delayed initiation, but did not improve Morris water maze performance.
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