THERAPY DOSSIER · th-1eb86cdf6db1

Selective brain cooling to 34 degrees C by extraluminal cooling of the bilateral common carotid arteries

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07526649 ↗NAnot yet recruiting

Head Cooling in Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy (COOLHEAD-2b)

Acute Ischemic Stroke

Enrolment: 182 · Results not recorded

NCT00383305 ↗NAcompleted

Brain-Cooling for the Treatment of Perinatal Hypoxic-Ischemic Encephalopathy (Cool-Cap)

Neonatal Hypoxic-Ischemic Encephalopathy

Enrolment: 235 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26684246 ↗2015Mixed findings

Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury.

RatTBIPenetrating / ballisticSprague-DawleyMaleExtraluminal cooling of the bilateral common carotid arteriesTarget brain temperature 34 degrees CInitiated immediately, or with a 2 h or 4 h delay after injury

Model: Penetrating ballistic-like brain injury

Selective brain cooling reduced lesion volume, axonal pathology, neuroinflammation and post-traumatic seizures and improved rotarod performance including after delayed initiation, but did not improve Morris water maze performance.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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