Effects of pharmaceutical formulations containing thyme on carbon tetrachloride-induced liver injury in rats.
RatChemical/toxinAlbino WistarMale and femalen = 6 per group across 6 groupsOral gavage, diluted with salineTincture 0.18 ml/kg/day; syrup 5.6 ml/kg/dayPretreatment daily for 7 days before the carbon tetrachloride challenge
Model: Acute liver injury from a single intraperitoneal dose of carbon tetrachloride in olive oil (1:3), 1 ml/kg, given 1 h after the final thyme dose on day 7
Both thyme preparations reduced hepatic lipid peroxidation and normalised antioxidant enzyme activities, but the tincture worsened serum AST and ALT while the syrup lowered them, and neither improved histological liver damage.
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