The effects of different environmental pH on healing of tympanic membrane: an experimental study.
RatWoundWistar albinoMalen = 20 rats in four groups, 40 earsTopical application to the left earStarted immediately after myringotomy
Model: Large myringotomy perforation in the posteroinferior quadrant of both tympanic membranes
Acidic pH 4 solution accelerated macroscopic closure by day 7 compared with pH 7, but was associated with significantly less fibroblastic activity at days 2 and 7.
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