Evidence & regulatory context
- Mechanism
- No ChEMBL entity (buffer solution). search_trials for topical pH 4 / acidic pH 4 skin care returned no trial administering a pH 4 versus pH 7 buffer; the top hits were unrelated topical agents and were rejected rather than recorded.
- Target
- Not recorded
- Injury models
- Wound
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatWoundWistar albinoMalen = 20 rats in four groups, 40 earsTopical application to the left earStarted immediately after myringotomy
Model: Large myringotomy perforation in the posteroinferior quadrant of both tympanic membranes
Acidic pH 4 solution accelerated macroscopic closure by day 7 compared with pH 7, but was associated with significantly less fibroblastic activity at days 2 and 7.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
