Inhibition of cyclooxygenase-1 and -2 activity in keratinocytes inhibits PGE formation and impairs vascular endothelial growth factor release and neovascularisation in skin wounds.

Inhibition of cyclooxygenase-1 and -2 activity in keratinocytes inhibits PGE formation and impairs vascular endothelial growth factor release and neovascularisation in skin wounds.

Model: Excisional full-thickness skin wound

Oral diclofenac lowered wound VEGF protein and impaired new blood vessel formation in acute wound tissue, consistent with reduced PGE2-triggered VEGF expression in wound keratinocytes.

Extraction: extract · Supplied extraction confidence: 0.35. Machine-extracted fields require source verification.