Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice.
MouseOtherPPAR-alpha null mice used alongside wild-typeMaleOralSodium butyrate 10 to 200 mg/kg; FBA 21.2 to 424 mg/kg (equ…
Model: Chronic constriction injury of the sciatic nerve, plus acetic acid and magnesium sulfate visceral pain and formalin tests
Oral sodium butyrate and FBA reduced visceral pain and formalin-evoked nociception in a dose- and time-dependent manner, and repeated dosing reduced mechanical and thermal hyperalgesia after chronic constriction injury.
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