Effects of Butyrate Enemas on Colonic Health
Healthy
Enrolment: 16 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy
Enrolment: 16 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Chronic constriction injury of the sciatic nerve, plus acetic acid and magnesium sulfate visceral pain and formalin tests
Oral sodium butyrate and FBA reduced visceral pain and formalin-evoked nociception in a dose- and time-dependent manner, and repeated dosing reduced mechanical and thermal hyperalgesia after chronic constriction injury.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: L-arginine-induced severe acute pancreatitis, two intraperitoneal injections of 20% L-arginine (200 mg/g)
Sodium butyrate improved pancreatic histopathology, lowered serum amylase, and reduced serum HMGB1, TNF-alpha and IL-6, HMGB1 mRNA and NF-kappaB activity relative to untreated severe acute pancreatitis animals.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Full-thickness third-degree dermal burn over 30 per cent total body surface area by immersion of template-exposed dorsal skin in 98 degrees Celsius water for 12 s under pentobarbital anaesthesia, causing remote acute lung injury
Sodium butyrate significantly suppressed burn-induced increases in bronchoalveolar lavage and serum TNF-alpha and IL-8, lung wet to dry ratio, histological injury score, myeloperoxidase activity and pulmonary HMGB1 expression, with most differences significant at 24 and 48 h. Lung wet to dry ratio…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.