Does enoxaparin interfere with HMGB1 signaling after TBI? A potential mechanism for reduced cerebral edema and neurologic recovery.
MouseTBIControlled cortical impactCD1Malen = n = 5 saline plus isotype; n = 6 each for the other three g…Enoxaparin and saline subcutaneous; antibody and isotype intravenous via jugular veinEnoxaparin 1 mg/kg (normal saline 1 mL/kg control); anti-HM…Enoxaparin or saline at 2, 8, 14, 23 and 32 h after injury; antibody or isotype…
Model: Severe controlled cortical impact traumatic brain injury, 4 mm craniotomy, 6 m/s velocity, 1.0 mm penetration, 3 mm impactor tip
Enoxaparin and anti-HMGB1 antibody each reduced pial leukocyte rolling (50.3 and 36.0 versus 125.6 leukocytes per 100 um per minute in vehicle), cerebral oedema and albumin leakage, and improved neurological scores, without additive effects on rolling or brain water. Combined treatment halved album…
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