Administration of low dose estrogen attenuates gliosis and protects neurons in acute spinal cord injury in rats.
RatSpinal cord injuryContusionSprague-DawleyMalen = 30 rats in total; n = 3 for each sham group and n = 6 for i…Intravenous, tail vein bolus1, 5, 10 or 100 ug/kg body weightFirst dose 15 min after injury
Model: Moderately severe contusion spinal cord injury at T10 (40 g.cm, 5 g weight dropped from 8 cm) after laminectomy; sham animals received laminectomy only
Low dose 17beta-oestradiol reduced GFAP reactivity, calpain and caspase-3 expression and activity, shifted the Bax:Bcl2 ratio towards survival and upregulated ERalpha, ERbeta and VEGF at 48 h. Neuronal TUNEL positivity was attenuated at 5 and 10 ug/kg, with 10 ug/kg as effective as 100 ug/kg.
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