Assessment of thermal treatment via irrigation of external ear to reduce cisplatin-induced hearing loss.
Guinea pigChemical/toxinMaleExternal auditory canal irrigationWater at 44 C, 37 C or 30 C (volume not stated)Acutely, immediately before cisplatin injection
Model: Cisplatin-induced ototoxicity and hearing loss, cisplatin 12 mg/kg intraperitoneally
Cool (30 C) ear canal irrigation significantly protected against cisplatin-induced hearing loss and outer hair cell loss, whereas warm (44 C) irrigation potentiated both.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.