THERAPY DOSSIER · th-3268632c984c

External ear canal irrigation with warm (44 C), euthermic (37 C) or cool (30 C) water

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: caloric vestibular stimulation; thermal vestibular stimulation
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05004194 ↗NAcompleted

Vestibular Caloric Stimulation and the Modulation of Pain in Fibromyalgia: An Open Label Pilot Study

Fibromyalgia

Enrolment: 21 · Results not recorded

NCT01629901 ↗NAcompleted

The Effect of Vestibular Stimulation on Cerebral Blood Flow (ThermoNeuroModulation device)

Healthy Volunteer

Enrolment: 10 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26639015 ↗2015Mixed findings

Assessment of thermal treatment via irrigation of external ear to reduce cisplatin-induced hearing loss.

Guinea pigChemical/toxinMaleExternal auditory canal irrigationWater at 44 C, 37 C or 30 C (volume not stated)Acutely, immediately before cisplatin injection

Model: Cisplatin-induced ototoxicity and hearing loss, cisplatin 12 mg/kg intraperitoneally

Cool (30 C) ear canal irrigation significantly protected against cisplatin-induced hearing loss and outer hair cell loss, whereas warm (44 C) irrigation potentiated both.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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