Apigenin Attenuates Inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury.
RatOtherWistarMalen = 126 male Wistar rats in total across three groupsEnteral (oral) feedingAfter induction of acute pancreatitis
Model: Acute pancreatitis induced by bilio-pancreatic duct obstruction close to the duodenum, with secondary acute lung injury
Apigenin reduced most histopathological alterations of lung tissue, lowered myeloperoxidase activity and TNF-alpha at 48 h and IL-6 at 72 h compared with untreated acute pancreatitis controls.
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