A novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury.
MixedChemical/toxinSprague-Dawley ratsMaleBath application in vitro; oral administration in vivo0.5 mM in vitro (5 h and 24 h pretreatment); 250 mg/kg in v…Pretreatment before chenodeoxycholic acid exposure
Model: Chenodeoxycholic acid-induced pancreatic ductal injury in isolated intra-interlobular ducts, and acute pancreatitis induced in rats by retrograde intraductal injection of 0.5% chenodeoxycholic acid
Pretreatment with 0.5 mM UDCA for 24 h reduced ATP depletion, mitochondrial injury and cell death caused by 1 mM chenodeoxycholic acid and fully prevented its inhibition of acid-base transport, while oral UDCA at 250 mg/kg markedly reduced the severity of chenodeoxycholic acid-induced acute pancrea…
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