Propranolol and Mesenchymal Stromal Cells Combine to Treat Traumatic Brain Injury.
RatTBIUnspecifiedSprague-DawleyMaleAcute propranolol dose followed by a delayed dose of mesenchymal stromal cells;…
Model: Moderate to severe traumatic brain injury in a rodent model; impact parameters not stated in the available text
Mesenchymal stromal cells reduced blood-brain barrier permeability at 96 h, limited thalamic microglial and macrophage activation short and long term and increased short-term neurogenesis, while propranolol reduced oedema and activated microglia. The sequential combination was well tolerated and im…
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