Intravenous multipotent adult progenitor cell treatment decreases inflammation leading to functional recovery following spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 159 rats in the main study, 30 for the 4 day post-injury mo…Intravenous, tail vein; a separate arm used intraspinal injectionIntravenous single doses of 1 x 10^5, 4 x 10^5, 1 x 10^6, 4…Intravenous either immediately after injury or one day post-injury; only the on…
Model: Contusive spinal cord injury at T8 using the Infinite Horizon impactor, 2.5 mm tip, 250 kDyne, after T8 laminectomy
A single intravenous dose of 4 x 10^6 MAPCs one day after injury improved locomotion (mean BBB 13.31 versus 10.63 for saline at 70 days), restored bladder and external urethral sphincter coordination, increased tissue sparing and shifted macrophages towards an alternatively activated phenotype. The…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.