THERAPY DOSSIER · th-113bea65d825

Human bone marrow derived multipotent adult progenitor cells (MAPCs)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03545607 ↗PHASE3terminated

MultiStem (MAPCs) Administration for Stroke Treatment and Enhanced Recovery (MASTERS-2)

Ischemic Stroke

Enrolment: 206 · Results not recorded

NCT01436487 ↗PHASE2completed

Phase 2 Safety and Efficacy Trial of MultiStem (MAPCs) in Adults With Ischemic Stroke

Ischemic Stroke

Enrolment: 134 · Results not recorded

NCT00677859 ↗PHASE1completed

Phase I Dose-Escalation of Allogeneic MultiStem (MAPCs) in Acute Leukemia/CML/MDS

Hematologic Malignancies

Enrolment: 36 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26582249 ↗2015Mixed findings

Intravenous multipotent adult progenitor cell treatment decreases inflammation leading to functional recovery following spinal cord injury.

RatSpinal cord injuryContusionSprague-DawleyFemalen = 159 rats in the main study, 30 for the 4 day post-injury mo…Intravenous, tail vein; a separate arm used intraspinal injectionIntravenous single doses of 1 x 10^5, 4 x 10^5, 1 x 10^6, 4…Intravenous either immediately after injury or one day post-injury; only the on…

Model: Contusive spinal cord injury at T8 using the Infinite Horizon impactor, 2.5 mm tip, 250 kDyne, after T8 laminectomy

A single intravenous dose of 4 x 10^6 MAPCs one day after injury improved locomotion (mean BBB 13.31 versus 10.63 for saline at 70 days), restored bladder and external urethral sphincter coordination, increased tissue sparing and shifted macrophages towards an alternatively activated phenotype. The…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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