Adipose Tissue-Derived Stem Cells Reduce Acute and Chronic Kidney Damage in Mice.
MouseChemical/toxinFVB/NJmalen = n = 2-7 per group depending on assayintraperitoneal1x10^6 cells per animal in sterile phosphate buffered saline24 h after folic acid
Model: Folic acid-induced nephrotoxic acute kidney injury (folic acid 200 mg/kg in 0.15 M sodium bicarbonate, intraperitoneal), with progression to chronic injury at 4 weeks
Adipose-derived stem cells lowered serum urea 48 h after folic acid, normalised tubular PCNA expression, reduced neutrophil infiltration and CXCL-1 and GM-CSF, and at 4 weeks reduced interstitial collagen, interferon gamma and eotaxin.
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