Adipose tissue derived mesenchymal stem cells as osteogenic component in composite grafts for proximal humeral fractures
Osteoporotic Fractures
Enrolment: 8 · Results not recorded
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Biologic · Syngeneic transfer has no human equivalent; the human analogue is autologous adipose-derived stem cells, which is what the recorded trials use (allogeneic in NCT04497805). NCT05797688 (chronic wounds) and NCT01532076 (humeral fracture) are the injury-repair indications and both closed early, WITHDRAWN at zero enrolment and TERMINATED at 8 respectively.
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Osteoporotic Fractures
Enrolment: 8 · Results not recorded
Wound of Skin
Enrolment: 0 · Results not recorded
Diabetic Foot Ulcer
Enrolment: 64 · Results not recorded
Type 1 Diabetes Mellitus
Enrolment: 30 · Results not recorded
Erectile Dysfunction · Cardiac Disease
Enrolment: 0 · Results not recorded
Skin Rejuvenation · Lipofilling
Enrolment: 15 · Results not recorded
Progressive Hemifacial Atrophy · Romberg's Disease
Enrolment: 5 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Folic acid-induced nephrotoxic acute kidney injury (folic acid 200 mg/kg in 0.15 M sodium bicarbonate, intraperitoneal), with progression to chronic injury at 4 weeks
Adipose-derived stem cells lowered serum urea 48 h after folic acid, normalised tubular PCNA expression, reduced neutrophil infiltration and CXCL-1 and GM-CSF, and at 4 weeks reduced interstitial collagen, interferon gamma and eotaxin.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.