Impact of Time on Fluid Resuscitation with Hypertonic Saline (NaCl 7.5%) in Rats with LPS-Induced Acute Lung Injury.
RatEndotoxin/LPSWistarMaleEarly versus late resuscitation, late given after the inflammatory scenario was…
Model: Bacterial lipopolysaccharide-induced acute lung injury
Late fluid resuscitation with hypertonic or normal saline did not reduce mortality and increased pulmonary inflammation, worsened pulmonary function and increased MMP-2 and MMP-9 activity and collagen deposition, unlike early treatment; the therapeutic window for benefit from hypertonic saline was…
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