Role of NOS2 in pulmonary injury and repair in response to bleomycin.
MouseChemical/toxinC57BL/6J and NOS2-/-Subcutaneous continuous infusion by osmotic pump implanted between the scapulae10 mg/kg/h, Alzet micro-osmotic pump model 1002 filled with…Started 6 days before intratracheal bleomycin
Model: Intratracheal bleomycin sulfate 3.0 U/kg in 50 microlitres saline
1400W reduced bronchoalveolar lavage nitrogen oxides (4.2 plus or minus 0.57 microM falling to 2.1 plus or minus 0.41 microM), cell counts, chemotactic activity, SNO-SP-D formation and IL-1beta, CCL2 and Ptgs2 expression, but did not attenuate trichrome fibrosis score (5 versus 0 for bleomycin vers…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.