The Role of Nitric Oxide Synthase Isoforms in the Cardiovascular Effects of Air Pollution
Endothelial Dysfunction
Enrolment: 16 · Results not recorded
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Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Endothelial Dysfunction
Enrolment: 16 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Acute hypobaric hypoxia and reoxygenation of the heart
Inhibiting iNOS with 1400W increased lipid peroxidation and apoptosis, indicating iNOS is protective in the hypoxic heart.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Intratracheal bleomycin sulfate 3.0 U/kg in 50 microlitres saline
1400W reduced bronchoalveolar lavage nitrogen oxides (4.2 plus or minus 0.57 microM falling to 2.1 plus or minus 0.41 microM), cell counts, chemotactic activity, SNO-SP-D formation and IL-1beta, CCL2 and Ptgs2 expression, but did not attenuate trichrome fibrosis score (5 versus 0 for bleomycin vers…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.