PRECLINICAL PUBLICATION · 2015

G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice.

Mouse / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Granulocyte colony-stimulating factor (G-CSF)

PMID 26524416 ↗2015Reported benefit

G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice.

MouseSpinal cord injuryHemisection / partialFemale

Model: Spinal cord hemisection

G-CSF accelerated autophagy activation in injured spinal cord and protected neuronal structure by inhibiting NF-kappaB signalling; blocking autophagy with 3-methyladenine partially removed the neuroprotective effect.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.