Neuroprotective effect of hydrogen sulfide on acute cauda equina injury in rats.
RatCrushSpinal crushSprague-DawleyMalen = 162 rats randomly allocated to three groupsIntraperitoneal20 micromol/kg body weight
Model: Cauda equina compression by implanting silicone gel (10 x 1 x 1 mm) into the epidural spaces at L5 and L6; laminectomy at L4 in sham
Hydrogen sulfide treatment improved myelin sheath and cauda equina fibre morphology and reduced the number of TUNEL positive cells relative to compression alone, and the authors concluded it reduced oxidative stress and was neuroprotective.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.