Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses.

Erythropoietin Protects Rat Brain Injury from Carbon Monoxide Poisoning by Inhibiting Toll-Like Receptor 4/NF-kappa B-Dependent Inflammatory Responses.

Model: Acute carbon monoxide poisoning induced brain injury

Erythropoietin suppressed the carbon monoxide induced upregulation of TLR4 and NF-kappaB and of TNF-alpha, IL-1beta and IL-6 in hippocampal tissue and reduced histological oedema and neuronal necrosis.

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