Puerarin attenuates severe burn-induced acute myocardial injury in rats.
RatBurnUnspecifiedWistarAdded to lactated Ringer's solution used for resuscitationGiven at resuscitation immediately after burn
Model: Third-degree burn over 30% of total body surface area with lactated Ringer's solution resuscitation
Puerarin reduced the burn-induced rise in serum creatine kinase MB and cardiac troponin T, improved cardiomyocyte ultrastructure, lowered serum TNF-alpha (control value 1.09 plus or minus 0.09 ng/ml, peaking at 12 h post burn in the burn group), suppressed cardiac myeloperoxidase activity and malon…
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