Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo.
MouseWoundNude miceTopical, as a nanofibrous bandage over the woundScaffolds loaded with 10, 20 or 30 wt % ibuprofen were scre…
Model: Full-thickness skin incision wound in nude mice
Both acellular and keratinocyte plus fibroblast seeded 20 wt % ibuprofen nanofibrous bandages reduced wound contraction relative to Tegaderm and sterile gauze. Newly regenerated skin under cell-seeded ibuprofen bandages showed significantly greater blood vessel formation than under acellular ibupro…
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